Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model마우스 모델에서 SARS-CoV-2 공격에 대한 보호 반응 유도에 대한 최적화된 서열과 SARS-CoV-2의 스파이크 단백질 야생형 DNA 서열의 비교Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acid Against Antiviral binding breath CD4 CD8+ cellular immune responses cellular immunity challenge clinical trial contributing to COVID-19 CTL demonstrated DNA DNA vaccine expression full-length spike protein hACE2 humoral humoral and cellular immunity IFN-γ immune immune responses immunogen in vitro induction mice Model mouse Neutralizing antibodies optimization optimizations pGX-9501 platform Protective Protective effects protective response RBD binding response robust SARS-CoV-2 sequence spike Spike protein subsequent T cell T cells the vaccine Transgenic mouse Type virus wild-type wild-type sequence. [DOI] 10.1080/21645515.2021.2016201 PMC 바로가기 [Article Type] Article
Reduced circulating FABP2 in patients with moderate to severe COVID-19 may indicate enterocyte functional change rather than cell deathArticle Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, 진단, [키워드] acid Alter alteration Biomarker caused cell death change circulating Cohort contribute COVID-19 COVID-19 patient disease dysfunction Europe exclusion FABP2 functional Gut immune include increase in Infection Inflammation Inflammatory responses inhibited marker median metabolites microbial product Mild moderate NMR outliers pathology Patient patients with moderate plasma Plasma marker positive correlation reduced reduction in route of infection SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease severe group Severity of disease shown systemic [DOI] 10.1038/s41598-022-23282-x PMC 바로가기
Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 SpikeArticle Published on 2022-10-262022-11-15 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acid acute respiratory syndrome addition addressed Amino acid amino acid substitution antigenic Antisera Care caused characterized coronavirus COVID-19 death demonstrated expressing expression level fitness FIVE GISAID globe greater Health highlight host immunity identifying Immune escape immune evasion immunological profile initiative Intervention L452 less lineages maintain mutant Mutation mutational studies Naturally neutralization pandemic phenotypic position promote pseudovirus retrieved SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant selected sensitivity sequence single nucleotide spike Spike protein Substitution substitution. T cell Transmissibility variants of concern viral evolution viral fitness viral infectivity virus VoC [DOI] 10.1128/jvi.01162-22 PMC 바로가기
A Rapid SARS-CoV-2 Nucleocapsid Protein Profiling Assay with High Sensitivity Comparable to Nucleic Acid DetectionArticle Published on 2022-10-252022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acid Antigen binding caused Concentration COVID-19 COVID-19 diagnosis detection DNA effective ELISA kits Epidemic Epidemics information limit of detection magnitude N protein nucleic acid nucleocapsid protein PCR Profiling Protein Rapid Region resulting Saliva SARS-CoV-2 sensitivity target protein The fluorescence intensity the N protein translation [DOI] 10.1021/acs.analchem.2c02670 PMC 바로가기
Safety, Tolerability, and Pharmacokinetics of the Novel Antiviral Agent Ensitrelvir Fumaric Acid, a SARS-CoV-2 3CL Protease Inhibitor, in Healthy AdultsArticle Published on 2022-10-182022-11-15 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL acid administration adverse event affected agent Antiviral assessment AUC C max COVID-19 demonstrated dose doses drug-drug interaction Effect ensitrelvir first-in-human Food Intake geometric increase in Infection inhibitor Japanese mild in severity MOST novel oral dosing P450 participant Participants participants with SARS-CoV-2 pharmacokinetics phase 1 study Placebo plasma proportionality protease Protease inhibitor protease inhibitor. Randomized reduced resolved Safety SARS-CoV-2 selective single dose substrate T max Tolerability Treatment viral replication [DOI] 10.1128/aac.00632-22 PMC 바로가기
(+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 VirusesArticle Published on 2022-09-292022-11-15 Journal: Viruses [Category] SARS, 치료제, [키워드] acid Antiviral antiviral action antiviral activity Antiviral compound binding site Compound compounds Delta derivative exhibit glycoprotein hemoglobin inhibitory activity main viral protease 3CLPro mechanism metabolite molecular Molecular modeling N-terminal domain omicron performed protease SARS-CoV-2 SARS-CoV-2 virus shown Spectrum strain Strains Surface glycoprotein surface glycoprotein S usnic acid virus virus SARS-CoV-2. Wuhan [DOI] 10.3390/v14102154 PMC 바로가기
Enhancing the Immunogenicity of RBD Protein Variants through Amino Acid E484 Mutation in SARS-CoV-2Article Published on 2022-09-132022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, 치료기술, [키워드] acid Antibody detection Antibody testing antigenic COVID-19 COVID-19 pandemic Critical E. coli E484K effective Effectiveness Enhancing Escherichia coli Evolution of SARS-CoV-2 expressed expression immunogenicity in vitro mice mutant mutant. mutants Neutralizing antibodies nine Protein raise RBD RBD protein recombinant RBD protein SARS-CoV-2 SARS-CoV-2 RBD protein single-point mutants the RBD protein vaccination Vaccine Vaccines variants western blotting wild type [DOI] 10.3390/v14092020 PMC 바로가기
Sialic Acid and Fucose Residues on the SARS-CoV-2 Receptor-Binding Domain Modulate IgG Antibody ReactivityArticle Published on 2022-09-092022-11-15 Journal: ACS Infectious Diseases [Category] SARS, 진단, [키워드] acid antibody antibody reactivity carbohydrate cells Chinese hamster conserved defined domain embryonic kidney cell ENhance evaluated exhibited fucose generate glycoepitope glycoproteomics IgG less mammalian cells mass spectrometry modulated monosaccharides N-linked glycans Neutralizing antibodies produced Protein RBD reactivity Receptor binding domain receptor binding domain. reduced removal SARS-CoV-2 SARS-CoV-2 positive patients serum sample sialic acid Spike protein Structure the RBD the RBD protein the SARS-CoV-2 vaccine candidates Viral proteins [DOI] 10.1021/acsinfecdis.2c00155 PMC 바로가기
Differential gene expression profiling reveals potential biomarkers and pharmacological compounds against SARS-CoV-2: Insights from machine learning and bioinformatics approachesArticle Published on 2022-08-172022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, 치료제, [키워드] acid approach bioinformatics caused Comorbidities complex interplay Compound contribute coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 progression Critical cyclosporine DEGs detect develop differentially expressed gene disease disease pathogenesis dysregulated E2F1 effort EGR1 expressed Factor functional functional enrichment Gene expression profiling Gene regulatory networks Genetic Genomics healthy controls healthy individual humans identify indicated individual individuals insight inter-individual Interaction machine learning approach MAX Mental mental retardation miRNA expression miRNAs nasopharyngeal network analysis offer Ontology overexpressed pandemic pathophysiology pathway pharmacological Potential biomarker Regulatory respiratory responsible reveal RNA-Seq RNA-seq data SARS-CoV-2 SARS-COV-2 infection Spread SRF TFS the SARS-CoV-2 therapeutic option therapeutic target therapeutic targets therapeutic targets. Vaccine Variability with COVID-19 YY1 [DOI] 10.3389/fimmu.2022.918692 PMC 바로가기
The Acid Ceramidase Is a SARS-CoV-2 Host Factor산성 세라미다제는 SARS-CoV-2 숙주 인자입니다Article Published on 2022-08-152022-09-11 Journal: Cells [Category] SARS, 변종, [키워드] accelerated acid acid sphingomyelinase analysis biochemical ceramidase ceramide Ceramides COVID-19 pandemic deacidify described down-regulate Effects enrichment Factor Fluoxetine fluoxetine. genomic Host hypothese hypotheses infected cells inhibit inhibitor interfere Lower lysosomal mRNA mRNAs Omicron variants ORF3 Protein reduce Replication reported RNA SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variants shown specific acid Support therapeutic strategy transmission rates Treatment variant viral entry viral gene expression viral replication [DOI] 10.3390/cells11162532 PMC 바로가기 [Article Type] Article